MYELOID NEOPLASIA Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia
نویسندگان
چکیده
1Inserm UMR866, Dijon; 2Faculty of Medicine, University of Burgundy, Dijon; 3Centre Hospitalier Universitaire (CHU) Le Bocage, CLIPP Platform, Dijon; 4Centre Georges François Leclerc, CLIPP Platform, Dijon; 5Hôpital Avicenne (Assistance Publique–Hôpitaux de Paris [APHP])/University Paris 13, Bobigny; 6Inserm U848, Institut Gustave Roussy/University Paris 11, Villejuif; 7CHU Lille, Lille; 8Hematology Department, Hôpital Cochin (APHP), Paris; 9Inserm U567, Paris; 10University Paris 5, Faculty of Medicine René Descartes, UM3, Paris; and 11Inserm U790, Institut Gustave Roussy/University Paris 11, Villejuif, France
منابع مشابه
Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that occurs in elderly patients. One of the main diagnostic criteria is the accumulation of heterogeneous monocytes in the peripheral blood. We further explored this cellular heterogeneity and observed that part of the leukemic clone in the peripheral blood was made of immature dysplastic granulocytes with a CD14(-)/CD24(...
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